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KMID : 0923620100100060247
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Immune Network
2010 Volume.10 No. 6 p.247 ~ p.249
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Presence of Foxp3-expressing CD19(＋)CD5(＋) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(＋)CD5(＋)Foxp3(＋) Regulatory B Cell (Breg)
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Noh Joon-Yong
Choi Wahn-Soo
Noh Geun-Woong
Lee Jae-Ho
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Abstract
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Foxp3 is a transcript factor for regulatory T cell development. Interestingly, Foxp3-expressing cells were identified in B cells, especially in CD19(＋)CD5(＋) B cells, while those were not examined in CD19(＋)CD5(?) B cells. Foxp3- expressing CD5(＋) B cells in this study were identified in human PBMCs and were found to consist of 8.5±3.5% of CD19(＋)CD5(＋) B cells. CD19(＋)CD5(＋)Foxp3(＋) B cells showed spontaneous apoptosis. Rare CD19(＋)CD5(＋) Foxp3(＋) regulatory B cell (Breg) population was unveiled in human peripheral blood mononuclear cells and suggested as possible regulatory B cells (Breg) as regulatory T cells (Treg). The immunologic and the clinical relevant of Breg needs to be further investigated.
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KEYWORD
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Foxp3, Regulatory B cell, Breg, CD5, CD19, CD5(＋) B
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